Profhilo vs Dermal Fillers – Which is Right for You?
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Profhilo and dermal fillers both hyaluronic acid, but they do completely things. Choosing them — or combining them — is one of the most common questions we field at consultation. The short version: dermal fillers add structure and volume to places, while Profhilo the hydration, elasticity, and quality of the skin itself.
This guide how each treatment works, where each one wins, and which to choose based on what you’re actually trying to fix.
The core difference in one paragraph
A dermal filler is a thicker, hyaluronic acid gel. When injected, it stays where you put it — that’s the whole point. It physically lifts and contours, volume in the cheeks, jawline, lips, tear trough, or chin. is a different animal: it’s a high-concentration, low-cross-linked hyaluronic acid that spreads after injection. It doesn’t lift or contour. Instead, it collagen and elastin production across a broad area, skin firmness, hydration, and “glow” without changing facial shape.
If your face has lost structural volume — flattened cheekbones, hollow temples, a jawline — you need filler. If your face still has good structure but the skin itself looks dull, crepey, or dehydrated, you need Profhilo. Plenty of patients in their late 30s and 40s need both.
How Profhilo works
Profhilo contains 64mg of acid in a 2ml syringe — one of the highest concentrations of any HA on the UK market. Crucially, it uses a manufacturing process to create hybrid cooperative complexes of high and low weight hyaluronic acid, chemical cross-linking agents. This because cross-linked fillers stay localised; Profhilo’s structure means it diffuses across the tissue plane after injection.
Once distributed, Profhilo stimulates four different types of and over the weeks. The clinical effects — tighter, more hydrated, more skin — build gradually over 4 to 8 weeks. There’s no immediate “before and after” the way there is with filler; is a slow burn.
The protocol is two four weeks apart, with visible from around week 4 of the second Keravive Hair Treatment and lasting roughly 6 months before a maintenance session.
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How dermal fillers work
are hyaluronic acid gels to hold their shape and stay in the anatomical layer where they’re placed. When injected deep on bone (cheekbones, chin, jawline), they structural support that has been lost to bone and . When more superficially (lips, tear trough, fine lines), they smooth and refine specific features.
The result is . You see the change as soon as you sit up. acid is hygroscopic, so the filler continues to attract water over the following 2 weeks, with the settled final result at around 2 to 4 weeks post-treatment.
Different filler have and lift capacities — the dense, products designed for deep cheek are different from the soft, flowing products for lips. We choose product based on anatomical site, not patient .
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Where each treatment goes
Dermal filler areas:
The overlap is small. doesn’t go in lips, tear troughs, or nose reshaping. Dermal fillers don’t go into broad sheets of skin for .
Treatment experience and downtime
Profhilo uses 10 standardised injection points across the lower face — 5 per side at chosen to maximise spread without compromising safety. The takes around 15 minutes. There’s no in Profhilo, so we apply anaesthetic cream first. You will see small raised bumps at each site after treatment; these within 24 to 48 hours as the . No in most cases, and you can return to work the same day.
Dermal fillers involve more variable technique — typically a combination of and cannulas, with injection points on the area. Most filler contain lidocaine, which numbs as it goes in. The procedure takes 20 to 45 minutes depending on the number of areas . Some and is normal, particularly with lip filler, where swelling can last 3 to 7 days. Most are socially presentable the next day; significant events should be at least 2 weeks out.
How long do the results last?
results last roughly 6 months from the second . Maintenance is usually 1 to 2 sessions per year depending on individual skin and lifestyle factors (sun exposure, smoking, and dehydration all shorten longevity).
Dermal fillers last anywhere from 6 to 24 months depending on product and placement. Lip (6 to 9 months); deep structural cheek and filler lasts longest (18 to 24 months). Tear trough sits in the middle (9 to 12 months).
In direct cost terms, dermal fillers are usually a longer-lasting per session. In terms of treatment intent, they’re not really — they solve different problems.
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Cost comparison
At Centre for Surgery, starts from £400 per session, with the full course of two sessions £750. Dermal start from £400 for a 1ml lip treatment and scale with the volume of used — full cheek is typically £900–£1,400 depending on volume; jawline £1,200–£2,400; tear trough £450–£700.
Cost should not be the driver of which treatment you choose. The right question is what your face actually needs — and that’s a consultation conversation, not a price comparison.
Who is each treatment best for?
Profhilo is the right answer when:
Dermal fillers are the right answer when:
Both at once when: you have both structural volume loss and skin concerns — which is most patients over 40. We typically do first, then layer in dermal fillers 2 to 4 weeks later, so we can assess each treatment’s effect independently.
What we don’t recommend
Profhilo is not a for filler. If you have hollow cheeks or under-eye troughs, Profhilo will not fix them. Patients sometimes ask for Profhilo because it’s been marketed as “natural” or “non-invasive” — both treatments are injectables, and both are made of acid. The is whether you need volume or skin .
Equally, dermal filler is not a substitute for . more filler into a face that needs skin quality improvement makes the skin look worse, not better. We see who have been the wrong outcome with the wrong treatment for years.
We do not offer polynucleotide skin boosters at all skin types or as a routine substitute for Profhilo — we do offer as a more intensive regenerative option, particularly under the eyes, but it’s a and not comparable.
Other skin booster options
isn’t the only skin booster, though it’s the most . Other acid skin boosters use lower and different strategies; results tend to be and more . We don’t use 1 for routine skin work — its and protocol are different from Profhilo, and we focus on the products with the strongest evidence base for the outcomes our are looking for.
For the tear trough specifically, we use 2, which is the only filler in our range specifically formulated for that anatomy. That’s a dermal filler, not a skin booster, and is a separate conversation from the Profhilo/filler .
Why choose Centre for Surgery?
We are a CQC-regulated clinic on Baker Street both Profhilo and dermal filler daily. All injectables are administered by GMC-registered doctors. We carry for filler complications and events. is structured, written, and includes a 2-week period before any .
Our consultation approach for Profhilo vs filler is to start with the question you actually want answered — what you when you look in the mirror? — and work backwards to the that addresses it. We won’t sell you if what you need is filler, and we won’t sell you filler if what you need is .
To book a consultation, call , email , or complete the contact form below.
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Centre for Surgery is a private hospital on London’s Baker Street, delivering plastic and surgery through GMC-registered surgeons. Our expertise spans facial and , , for men, and body contouring procedures such as and . Patient safety, excellence and natural-looking results sit at the heart of everything we do.
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